Custom DNA-binding proteins come of age: polydactyl zinc-finger proteins.
نویسندگان
چکیده
Artificial transcription factors based on modified zinc-finger DNA-binding domains have been shown to activate or repress the transcription of endogenous genes in multiple organisms. Advances in both the construction of novel zinc-finger proteins and our understanding of the characteristics of a productive regulatory site have fueled these achievements.
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عنوان ژورنال:
- Current opinion in biotechnology
دوره 12 6 شماره
صفحات -
تاریخ انتشار 2001